USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P23246 USC-OGP 2-DE database:  P23246 P23246 General information about the entry View entry in simple text format Entry name SFPQ_HUMAN Primary accession number P23246 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Splicing factor, proline-and glutamine-rich; AltName: Full=100 kDa DNA-pairing protein; Short=hPOMp100; AltName: Full=DNA-binding p52/p100 complex, 100 kDa subunit; AltName: Full=Polypyrimidine tract-binding protein-associated-splicing factor {ECO:0000303|PubMed:9848648}; Short=PSF {ECO:0000303|PubMed:8449401}; Short=PTB-associated-splicing factor;. Gene name Name=SFPQ Synonyms=PSF Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1105: pI=5.51; Mw=115893 Cross-references UniProtKB/Swiss-Prot P23246; SFPQ_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SFPQ_HUMAN Primary accession number P23246 Secondary accession number(s) P30808 Q5SZ71 Sequence was last modified on  October 1, 1996 (version 2) Annotations were last modified on  March 15, 2017 (version 193) Name and origin of the protein Description RecName: Full=Splicing factor, proline-and glutamine-rich; AltName: Full=100 kDa DNA-pairing protein; Short=hPOMp100; AltName: Full=DNA-binding p52/p100 complex, 100 kDa subunit; AltName: Full=Polypyrimidine tract-binding protein-associated-splicing factor {ECO:0000303|PubMed:9848648}; Short=PSF {ECO:0000303|PubMed:8449401}; Short=PTB-associated-splicing factor; Gene name Name=SFPQ Synonyms=PSF Encoded on Name=SFPQ; Synonyms=PSF Keywords 3D-structure; Acetylation; Activator; Alternative splicing; Biological rhythms; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA-binding; Isopeptide bond; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X70944; CAA50283.1; -; mRNA EMBL AL590434; CAI12467.1; -; Genomic_DNA EMBL CH471059; EAX07426.1; -; Genomic_DNA EMBL X16850; CAA34747.1; -; mRNA CCDS CCDS388.1; -. [P23246-1]; . PIR A46302; A46302; . PIR S29770; S29770; . RefSeq NP_005057.1; NM_005066.2. [P23246-1]; . RefSeq XP_005271169.1; XM_005271112.4. [P23246-1]; . RefSeq XP_005271170.1; XM_005271113.4. [P23246-1]; . RefSeq XP_005271172.1; XM_005271115.4. [P23246-2]; . RefSeq XP_016857542.1; XM_017002053.1. [P23246-1]; . RefSeq XP_016857543.1; XM_017002054.1. [P23246-1]; . UniGene Hs.355934; -; . UniGene Hs.611911; -; . PDB 4WII; X-ray; 2.05 A; A/B=276-535 PDB 4WIJ; X-ray; 3.49 A; A/B=276-598 PDB 4WIK; X-ray; 3.00 A; A/B=369-598 PDBsum 4WII; -; . PDBsum 4WIJ; -; . PDBsum 4WIK; -; . ProteinModelPortal P23246; -; . SMR P23246; -; . BioGrid 112319; 195; . DIP DIP-31272N; -; . IntAct P23246; 60; . MINT MINT-1141893; -; . STRING 9606.ENSP00000349748; -; . iPTMnet P23246; -; . PhosphoSitePlus P23246; -; . SwissPalm P23246; -; . BioMuta SFPQ; -; . DMDM 1709851; -; . SWISS-2DPAGE P23246; -; . EPD P23246; -; . MaxQB P23246; -; . PaxDb P23246; -; . PeptideAtlas P23246; -; . PRIDE P23246; -; . Ensembl ENST00000357214; ENSP00000349748; ENSG00000116560. [P23246-1]; . GeneID 6421; -; . KEGG hsa:6421; -; . UCSC uc001bys.4; human. [P23246-1]; . CTD 6421; -; . DisGeNET 6421; -; . GeneCards SFPQ; -; . HGNC HGNC:10774; SFPQ; . HPA CAB009886; -; . HPA HPA047513; -; . HPA HPA054689; -; . MalaCards SFPQ; -; . MIM 605199; gene; . neXtProt NX_P23246; -; . OpenTargets ENSG00000116560; -; . Orphanet 319308; Translocation renal cell carcinoma; . PharmGKB PA35690; -; . eggNOG KOG0115; Eukaryota; . eggNOG ENOG410XQA0; LUCA; . GeneTree ENSGT00390000005004; -; . HOGENOM HOG000231095; -; . HOVERGEN HBG009801; -; . InParanoid P23246; -; . KO K13219; -; . OMA GRQHHAP; -; . OrthoDB EOG091G09T7; -; . PhylomeDB P23246; -; . TreeFam TF315795; -; . Reactome R-HSA-8849468; PTK6 Regulates Proteins Involved in RNA Processing; . SIGNOR P23246; -; . ChiTaRS SFPQ; human; . GeneWiki SFPQ; -; . GenomeRNAi 6421; -; . PRO PR:P23246; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000116560; -; . CleanEx HS_SFPQ; -; . ExpressionAtlas P23246; baseline and differential; . Genevisible P23246; HS; . GO GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL; . GO GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0016363; C:nuclear matrix; IDA:BHF-UCL; . GO GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell; . GO GO:0005654; C:nucleoplasm; IDA:BHF-UCL; . GO GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL; . GO GO:0042382; C:paraspeckles; IDA:UniProtKB; . GO GO:0090575; C:RNA polymerase II transcription factor complex; ISS:BHF-UCL; . GO GO:0003682; F:chromatin binding; ISS:BHF-UCL; . GO GO:0001047; F:core promoter binding; ISS:UniProtKB; . GO GO:0003677; F:DNA binding; IDA:UniProtKB; . GO GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL; . GO GO:0000166; F:nucleotide binding; IEA:InterPro; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISS:BHF-UCL; . GO GO:0044212; F:transcription regulatory region DNA binding; IDA:ParkinsonsUK-UCL; . GO GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISS:UniProtKB; . GO GO:0000380; P:alternative mRNA splicing; via spliceosome; IMP:BHF-UCL GO GO:0000724; P:double-strand break repair via homologous recombination; IMP:MGI; . GO GO:0070932; P:histone H3 deacetylation; ISS:UniProtKB; . GO GO:0006397; P:mRNA processing; TAS:ProtInc; . GO GO:0042754; P:negative regulation of circadian rhythm; ISS:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; ISS:UniProtKB GO GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL; . GO GO:0045876; P:positive regulation of sister chromatid cohesion; IEA:Ensembl; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB; . GO GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB; . GO GO:0048511; P:rhythmic process; IEA:UniProtKB-KW; . GO GO:0008380; P:RNA splicing; TAS:ProtInc; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW Gene3D 3.30.70.330; -; 2; . InterPro IPR012975; NOPS; . InterPro IPR012677; Nucleotide-bd_a/b_plait; . InterPro IPR000504; RRM_dom; . Pfam PF08075; NOPS; 1; . Pfam PF00076; RRM_1; 2; . SMART SM00360; RRM; 2; . SUPFAM SSF54928; SSF54928; 1; . PROSITE PS50102; RRM; 2; .

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